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InnateDB Protein
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IDBP-79241.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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VDAC2
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Protein Name
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voltage-dependent anion channel 2
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Synonyms
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POR;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000298468
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InnateDB Gene
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IDBG-79237 (VDAC2)
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Protein Structure
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| Function |
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective.
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| Subcellular Localization |
Mitochondrion outer membrane {ECO:0000269PubMed:7539795}.
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| Disease Associations |
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| Tissue Specificity |
Expressed in all tissues examined.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
60
[view]
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| Protein-Protein |
57
[view]
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| Protein-DNA |
3
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
2 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0008308
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voltage-gated anion channel activity
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR001925
Porin, eukaryotic type
IPR027246
Eukaryotic porin/Tom40
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| PFAM |
PF01459
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| PRINTS |
PR00185
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-P45880
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| TrEMBL |
Q5JSD2
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| UniProt Splice Variant |
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| Entrez Gene |
7417
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| UniGene |
Hs.605824
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| RefSeq |
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| HUGO |
HGNC:12672
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| OMIM |
193245
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| CCDS |
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| HPRD |
01904
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| IMGT |
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| EMBL |
AL390034
AL392111
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| GenPept |
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Version 5.4