InnateDB Protein
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IDBP-79248.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ICOS
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Protein Name
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inducible T-cell co-stimulator
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000319476
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InnateDB Gene
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IDBG-79246 (ICOS)
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Protein Structure
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Function |
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). {ECO:0000250}.
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Subcellular Localization |
Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 2: Secreted {ECO:0000305}.
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Disease Associations |
Immunodeficiency, common variable, 1 (CVID1) [MIM:607594]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269PubMed:12577056}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. {ECO:0000269PubMed:11006126, ECO:0000269PubMed:11169414, ECO:0000269PubMed:9930702}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
3
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y6W8
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PhosphoSite |
PhosphoSite-Q9Y6W8
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TrEMBL |
Q53QY6
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UniProt Splice Variant |
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Entrez Gene |
29851
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UniGene |
Hs.627040
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RefSeq |
NP_036224
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HUGO |
HGNC:5351
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OMIM |
604558
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CCDS |
CCDS2363
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HPRD |
09196
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IMGT |
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EMBL |
AB023135
AC103880
AF218312
AF411058
AF411059
AF488346
AF488347
AJ277832
AJ535718
AK314985
BC028006
BC028210
CH471063
EF064727
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GenPept |
AAF71301
AAH28006
AAH28210
AAL40933
AAL40934
AAM00909
AAX93073
ABK41910
BAA82129
BAG37484
CAC06612
CAD59742
EAW70356
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