Version 5.4
Homo sapiens Gene: ICOS
Summary
InnateDB Gene IDBG-79246.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ICOS
Gene Name inducible T-cell co-stimulator
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163600
Encoded Proteins
IDBP-79248
inducible T-cell co-stimulator
IDBP-388516
inducible T-cell co-stimulator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:203936748-203961577
Strand Forward strand
Band q33.2
Transcripts
ENST00000316386 ENSP00000319476
ENST00000435193 ENSP00000415951
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 3 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002517 T cell tolerance induction
GO:0006955 immune response
GO:0016337 single organismal cell-cell adhesion
GO:0031295 T cell costimulation
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026009
View Gene Order
ENSBTAG00000021596
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04660
T cell receptor signaling pathway pathway
hsa05340
Primary immunodeficiency pathway
hsa04672
Intestinal immune network for IgA production pathway
INOH
PID NCI
Cross-References
SwissProt Q9Y6W8
TrEMBL Q53QY6
UniProt Splice Variant
Entrez Gene 29851
UniGene Hs.56247 Hs.627040
RefSeq NM_012092 XM_005246482
HUGO HGNC:5351
OMIM 604558
CCDS CCDS2363
HPRD 09196
IMGT
EMBL AB023135 AC103880 AF218312 AF411058 AF411059 AF488346 AF488347 AJ277832 AJ535718 AK314985 BC028006 BC028210 CH471063 EF064727
GenPept AAF71301 AAH28006 AAH28210 AAL40933 AAL40934 AAM00909 AAX93073 ABK41910 BAA82129 BAG37484 CAC06612 CAD59742 EAW70356
RNA Seq Atlas 29851

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca