InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSTF2

Summary

InnateDB Protein

IDBP-79283.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSTF2

Protein Name

cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa

Synonyms

CstF-64;

Species

Homo sapiens

Ensembl Protein

ENSP00000362063

InnateDB Gene

IDBG-79279 (CSTF2)

Protein Structure

UniProt Annotation

Function

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11598190}. Note=Localized with DDX1 in cleavage bodies.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.

Experimentally validated
Total	61 [view]
Protein-Protein	61 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006378	mRNA polyadenylation
GO:0006379	mRNA cleavage
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing