InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NRP2

Summary

InnateDB Protein

IDBP-79332.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRP2

Protein Name

neuropilin 2

Synonyms

NP2; NPN2; PRO2714; VEGF165R2;

Species

Homo sapiens

Ensembl Protein

ENSP00000349632

InnateDB Gene

IDBG-79320 (NRP2)

Protein Structure

UniProt Annotation

Function

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

Subcellular Localization

Membrane; Single-pass type I membrane protein.Isoform s9: Secreted {ECO:0000269PubMed:11112349}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0008201	heparin binding
GO:0017154	semaphorin receptor activity
GO:0019838	growth factor binding
GO:0019955	cytokine binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0010595	positive regulation of endothelial cell migration
GO:0021675	nerve development
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048846	axon extension involved in axon guidance
GO:0061549	sympathetic ganglion development
GO:0097490	sympathetic neuron projection extension
GO:0097491	sympathetic neuron projection guidance
GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance

Cellular Component

GO:0002116	semaphorin receptor complex
GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR000859 CUB domain
IPR000998 MAM domain
IPR008979 Galactose-binding domain-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR014648 Neuropilin
IPR022579 Neuropilin-1, C-terminal

PFAM

PF00754
PF00431
PF00629
PF11980

PRINTS

PR00020

PIRSF

PIRSF036960

SMART

SM00231
SM00042
SM00137

TIGRFAMs

Post-translational Modifications

Modification

Cross-References