InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NRP2

Summary

InnateDB Gene

IDBG-79320.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRP2

Gene Name

neuropilin 2

Synonyms

NP2; NPN2; PRO2714; VEGF165R2

Species

Homo sapiens

Ensembl Gene

ENSG00000118257

Encoded Proteins

IDBP-79324

neuropilin 2

IDBP-79326

neuropilin 2

IDBP-79330

neuropilin 2

IDBP-79332

neuropilin 2

IDBP-388536

neuropilin 2

IDBP-388537

neuropilin 2

IDBP-388538

neuropilin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:205681990-205798133

Strand

Forward strand

Band

q33.3

Transcripts

ENST00000360409	ENSP00000353582
ENST00000357785	ENSP00000350432
ENST00000272849	ENSP00000272849
ENST00000357118	ENSP00000349632
ENST00000412873	ENSP00000407626
ENST00000450507	ENSP00000404279
ENST00000417189	ENSP00000387519
ENST00000464003
ENST00000478013
ENST00000483917
ENST00000477199
ENST00000478054
ENST00000460987
ENST00000468256
ENST00000485684
ENST00000472299
ENST00000467850

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0017154	semaphorin receptor activity
GO:0019838	growth factor binding
GO:0019955	cytokine binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001755	neural crest cell migration
GO:0001764	neuron migration
GO:0001938	positive regulation of endothelial cell proliferation
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0007507	heart development
GO:0010595	positive regulation of endothelial cell migration
GO:0021675	nerve development
GO:0021828	gonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048846	axon extension involved in axon guidance
GO:0050919	negative chemotaxis
GO:0061549	sympathetic ganglion development
GO:0097490	sympathetic neuron projection extension
GO:0097491	sympathetic neuron projection guidance
GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance

Cellular Component

GO:0002116	semaphorin receptor complex
GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon