InnateDB Protein
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IDBP-7937.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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APOBEC3D
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Protein Name
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apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000216099
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InnateDB Gene
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IDBG-402334 (APOBEC3D)
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Protein Structure
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Function |
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons. {ECO:0000269PubMed:12859895, ECO:0000269PubMed:20062055, ECO:0000269PubMed:21835787, ECO:0000269PubMed:22807680, ECO:0000269PubMed:23097438, ECO:0000269PubMed:23152537}.
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Subcellular Localization |
Cytoplasm. Cytoplasm, P-body.
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Disease Associations |
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Tissue Specificity |
Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung. {ECO:0000269PubMed:20308164}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0010529
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negative regulation of transposition
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GO:0045087
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innate immune response
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GO:0045869
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negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
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GO:0051607
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defense response to virus
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GO:0070383
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DNA cytosine deamination
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Cellular Component |
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PDB ID |
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InterPro |
IPR007904
APOBEC-like, C-terminal
IPR013158
APOBEC-like, N-terminal
IPR016193
Cytidine deaminase-like
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PFAM |
PF05240
PF08210
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96AK3
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PhosphoSite |
PhosphoSite-Q96AK3
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TrEMBL |
B2CML4
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UniProt Splice Variant |
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Entrez Gene |
140564
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UniGene |
Hs.658626
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RefSeq |
NP_689639
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HUGO |
HGNC:17354
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OMIM |
609900
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CCDS |
CCDS46709
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HPRD |
16501
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IMGT |
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EMBL |
AL022318
CH471095
EU527884
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GenPept |
ACB32248
CAI17899
EAW60285
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