InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APOBEC3D

Summary

InnateDB Protein

IDBP-7939.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOBEC3D

Protein Name

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000370980

InnateDB Gene

IDBG-402334 (APOBEC3D)

Protein Structure

UniProt Annotation

Function

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons. {ECO:0000269PubMed:12859895, ECO:0000269PubMed:20062055, ECO:0000269PubMed:21835787, ECO:0000269PubMed:22807680, ECO:0000269PubMed:23097438, ECO:0000269PubMed:23152537}.

Subcellular Localization

Cytoplasm. Cytoplasm, P-body.

Disease Associations

Tissue Specificity

Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung. {ECO:0000269PubMed:20308164}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

Biological Process

GO:0010529	negative regulation of transposition
GO:0045087	innate immune response
GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0051607	defense response to virus
GO:0070383	DNA cytosine deamination