InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC2A10

Summary

InnateDB Protein

IDBP-79450.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC2A10

Protein Name

solute carrier family 2 (facilitated glucose transporter), member 10

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000352216

InnateDB Gene

IDBG-79448 (SLC2A10)

Protein Structure

UniProt Annotation

Function

Facilitative glucose transporter.

Subcellular Localization

Endomembrane system {ECO:0000269PubMed:16550171}; Multi-pass membrane protein {ECO:0000269PubMed:16550171}. Cytoplasm, perinuclear region {ECO:0000269PubMed:16550171}.

Disease Associations

Arterial tortuosity syndrome (ATS) [MIM:208050]: An autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries. {ECO:0000269PubMed:16550171, ECO:0000269PubMed:17935213}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed; highest levels in liver and pancreas. {ECO:0000269PubMed:11592815}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005351	sugar:proton symporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0015758	glucose transport
GO:0015992	proton transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0012505	endomembrane system
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR003663 Sugar/inositol transporter
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PR00171

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95528