InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EYA2

Summary

InnateDB Protein

IDBP-79459.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EYA2

Protein Name

eyes absent homolog 2 (Drosophila)

Synonyms

EAB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000333640

InnateDB Gene

IDBG-79457 (EYA2)

Protein Structure

UniProt Annotation

Function

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1. {ECO:0000269PubMed:19351884, ECO:0000269PubMed:21706047}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Retained in the cytoplasm via interaction with GNAZ and GNAI2. Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus.

Disease Associations

Tissue Specificity

Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006470	protein dephosphorylation
GO:0007275	multicellular organismal development
GO:0007501	mesodermal cell fate specification
GO:0014706	striated muscle tissue development
GO:0016576	histone dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097345	mitochondrial outer membrane permeabilization