InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EYA2

Summary

InnateDB Gene

IDBG-79457.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EYA2

Gene Name

eyes absent homolog 2 (Drosophila)

Synonyms

EAB1

Species

Homo sapiens

Ensembl Gene

ENSG00000064655

Encoded Proteins

IDBP-79459

eyes absent homolog 2 (Drosophila)

IDBP-79461

eyes absent homolog 2 (Drosophila)

IDBP-79467

eyes absent homolog 2 (Drosophila)

IDBP-377458

eyes absent homolog 2 (Drosophila)

IDBP-483543

eyes absent homolog 2 (Drosophila)

IDBP-812447

EYA transcriptional coactivator and phosphatase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined. [provided by RefSeq, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:46894624-47188844

Strand

Forward strand

Band

q13.12

Transcripts

ENST00000327619	ENSP00000333640
ENST00000357410	ENSP00000349986
ENST00000317304	ENSP00000321590
ENST00000458636	ENSP00000395427
ENST00000497062	ENSP00000417105
ENST00000497428
ENST00000479843
ENST00000471081
ENST00000475856
ENST00000611592	ENSP00000483392

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006470	protein dephosphorylation
GO:0007275	multicellular organismal development
GO:0007501	mesodermal cell fate specification
GO:0014706	striated muscle tissue development
GO:0016576	histone dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097345	mitochondrial outer membrane permeabilization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000017897

View Gene Order

ENSBTAG00000013336

Not yet available

Cross-References

SwissProt

O00167

TrEMBL

B1AKW3 E7ETN2 O60647

UniProt Splice Variant

Entrez Gene

2139

UniGene

Hs.607241 Hs.722040 Hs.722415 Hs.722416

RefSeq

NM_005244 NM_172110

HUGO

HGNC:3520

OMIM

601654

CCDS

CCDS13403 CCDS54471

HPRD

IMGT

EMBL

AF055015 AJ007992 AL022342 AL049540 AL121776 AL354766 AL359434 AL390211 BC000289 BC008803 BC013882 BT006682 U71207 U81601 Y10261

GenPept

AAB42065 AAB51120 AAC09362 AAH00289 AAH08803 AAH13882 AAP35328 CAA07815 CAA71310 CAI23166 CAI40099 CAI42150

RNA Seq Atlas

2139