InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLF7

Summary

InnateDB Protein

IDBP-79550.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLF7

Protein Name

Kruppel-like factor 7 (ubiquitous)

Synonyms

UKLF;

Species

Homo sapiens

Ensembl Protein

ENSP00000309570

InnateDB Gene

IDBG-79548 (KLF7)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous and highly expressed in brain and spinal cord in the adult, and in kidney and brain in the embryo.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048813	dendrite morphogenesis