Version 5.4
Homo sapiens Gene: KLF7
Summary
InnateDB Gene IDBG-79548.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLF7
Gene Name Kruppel-like factor 7 (ubiquitous)
Synonyms UKLF
Species Homo sapiens
Ensembl Gene ENSG00000118263
Encoded Proteins
IDBP-79550
Kruppel-like factor 7 (ubiquitous)
IDBP-381235
Kruppel-like factor 7 (ubiquitous)
IDBP-388591
Kruppel-like factor 7 (ubiquitous)
IDBP-388592
Kruppel-like factor 7 (ubiquitous)
IDBP-388595
Kruppel-like factor 7 (ubiquitous)
IDBP-388596
Kruppel-like factor 7 (ubiquitous)
IDBP-388599
Kruppel-like factor 7 (ubiquitous)
IDBP-388600
Kruppel-like factor 7 (ubiquitous)
IDBP-388601
Kruppel-like factor 7 (ubiquitous)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:207074137-207167267
Strand Reverse strand
Band q33.3
Transcripts
ENST00000309446 ENSP00000309570
ENST00000412414 ENSP00000403284
ENST00000421199 ENSP00000387510
ENST00000423015 ENSP00000398572
ENST00000458272 ENSP00000393268
ENST00000435602 ENSP00000413590
ENST00000426163 ENSP00000397245
ENST00000457962 ENSP00000392015
ENST00000451244 ENSP00000412950
ENST00000467833
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048813 dendrite morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025959
View Gene Order
ENSBTAG00000044097
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.59908 Hs.626930
RefSeq NM_001270942 NM_001270943 NM_001270944 NM_003709 XM_005246926 XM_006712815 XM_006712816
HUGO
OMIM
CCDS CCDS2373 CCDS59438 CCDS59439 CCDS59440
HPRD 07279
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca