InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNMA1

Summary

InnateDB Protein

IDBP-79638.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNMA1

Protein Name

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

Synonyms

bA205K10.1; BKTM; KCa1.1; MaxiK; mSLO1; SAKCA; SLO; SLO-ALPHA; SLO1;

Species

Homo sapiens

Ensembl Protein

ENSP00000346321

InnateDB Gene

IDBG-79612 (KCNMA1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding
GO:0015269	calcium-activated potassium channel activity
GO:0046872	metal ion binding
GO:0060072	large conductance calcium-activated potassium channel activity

Biological Process

GO:0001666	response to hypoxia
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0006970	response to osmotic stress
GO:0007268	synaptic transmission
GO:0007596	blood coagulation
GO:0030007	cellular potassium ion homeostasis
GO:0034465	response to carbon monoxide
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0043065	positive regulation of apoptotic process
GO:0045794	negative regulation of cell volume
GO:0051592	response to calcium ion
GO:0055085	transmembrane transport
GO:0060073	micturition
GO:0060083	smooth muscle contraction involved in micturition
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005901	caveola
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003091 Potassium channel
IPR003148 Regulator of K+ conductance, N-terminal
IPR003929 Potassium channel, calcium-activated, BK, alpha subunit
IPR005821 Ion transport domain
IPR013099 Two pore domain potassium channel domain

PFAM

PF02254
PF03493
PF00520
PF07885

PRINTS

PR00169
PR01449

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q12791