InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RDBP

Summary

InnateDB Protein

IDBP-79700.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RDBP

Protein Name

RD RNA binding protein

Synonyms

D6S45; NELF-E; RD; RDBP; RDP;

Species

Homo sapiens

Ensembl Protein

ENSP00000364578

InnateDB Gene

IDBG-79698 (RDBP)

Protein Structure

UniProt Annotation

Function

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269PubMed:10199401, ECO:0000269PubMed:11940650, ECO:0000269PubMed:12612062}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:12612062}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0008150	biological_process
GO:0010467	gene expression
GO:0016032	viral process
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter
GO:0050434	positive regulation of viral transcription