InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RDBP

Summary

InnateDB Gene

IDBG-79698.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RDBP

Gene Name

RD RNA binding protein

Synonyms

D6S45; NELF-E; RD; RDBP; RDP

Species

Homo sapiens

Ensembl Gene

ENSG00000204356

Encoded Proteins

IDBP-79700

RD RNA binding protein

IDBP-79702

RD RNA binding protein

IDBP-373522

RD RNA binding protein

IDBP-373527

RD RNA binding protein

IDBP-373529

RD RNA binding protein

IDBP-373531

RD RNA binding protein

IDBP-373533

RD RNA binding protein

IDBP-481015

RD RNA binding protein

IDBP-481998

RD RNA binding protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:31952087-31959110

Strand

Reverse strand

Band

p21.33

Transcripts

ENST00000375429	ENSP00000364578
ENST00000375425	ENSP00000364574
ENST00000444811	ENSP00000388400
ENST00000441998	ENSP00000397914
ENST00000454913	ENSP00000409389
ENST00000436289	ENSP00000414029
ENST00000426722	ENSP00000394340
ENST00000492185
ENST00000488426
ENST00000481121
ENST00000492539	ENSP00000419183
ENST00000491139
ENST00000494956	ENSP00000420205

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003746	translation elongation factor activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006414	translational elongation
GO:0008150	biological_process
GO:0010467	gene expression
GO:0016032	viral process
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter
GO:0050434	positive regulation of viral transcription