InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SKIV2L

Summary

InnateDB Protein

IDBP-79740.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SKIV2L

Protein Name

superkiller viralicidic activity 2-like (S. cerevisiae)

Synonyms

170A; DDX13; HLP; SKI2; SKI2W; SKIV2; THES2;

Species

Homo sapiens

Ensembl Protein

ENSP00000364543

InnateDB Gene

IDBG-79738 (SKIV2L)

Protein Structure

UniProt Annotation

Function

Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).

Subcellular Localization

Nucleus {ECO:0000305}. Cytoplasm {ECO:0000305}.

Disease Associations

Trichohepatoenteric syndrome 2 (THES2) [MIM:614602]: A syndrome characterized by intrauterine growth retardation, severe diarrhea in infancy requiring total parenteral nutrition, facial dysmorphism, immunodeficiency, and hair abnormalities, mostly trichorrhexis nodosa. Hepatic involvement contributes to the poor prognosis of affected patients. {ECO:0000269PubMed:22444670}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004004	ATP-dependent RNA helicase activity
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Biological Process

GO:0006200	ATP catabolic process
GO:0008152	metabolic process

Cellular Component

GO:0005634	nucleus
GO:0055087	Ski complex

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR012961 DSH, C-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR016438 RNA helicase, ATP-dependent, SK12/DOB1
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270
PF08148

PRINTS

PIRSF

PIRSF005198

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt