Homo sapiens Gene: SKIV2L
Summary
InnateDB Gene IDBG-79738.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SKIV2L
Gene Name superkiller viralicidic activity 2-like (S. cerevisiae)
Synonyms 170A; DDX13; HLP; SKI2; SKI2W; SKIV2; THES2
Species Homo sapiens
Ensembl Gene ENSG00000204351
Encoded Proteins
superkiller viralicidic activity 2-like (S. cerevisiae)
superkiller viralicidic activity 2-like (S. cerevisiae)
superkiller viralicidic activity 2-like (S. cerevisiae)
superkiller viralicidic activity 2-like (S. cerevisiae)
superkiller viralicidic activity 2-like (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31959080-31969755
Strand Forward strand
Band p21.33
Transcripts
ENST00000375394 ENSP00000364543
ENST00000488648
ENST00000465703
ENST00000461073 ENSP00000419905
ENST00000474839 ENSP00000420470
ENST00000492900
ENST00000466290
ENST00000461915
ENST00000494058
ENST00000484835
ENST00000483553 ENSP00000420332
ENST00000471818
ENST00000485349
ENST00000491994 ENSP00000417586
ENST00000470453
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016817 hydrolase activity, acting on acid anhydrides
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Biological Process
GO:0006200 ATP catabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0055087 Ski complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Association of TriC/CCT with target proteins during biosynthesis pathway
Protein folding pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
KEGG
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.89864
RefSeq NM_006929 XM_006715168 XM_006725497
HUGO
OMIM
CCDS CCDS4731
HPRD 02724
IMGT
EMBL
GenPept
RNA Seq Atlas