InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLF4

Summary

InnateDB Protein

IDBP-79822.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLF4

Protein Name

Kruppel-like factor 4 (gut)

Synonyms

EZF; GKLF;

Species

Homo sapiens

Ensembl Protein

ENSP00000363804

InnateDB Gene

IDBG-79820 (KLF4)

Protein Structure

UniProt Annotation

Function

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. {ECO:0000269PubMed:17308127, ECO:0000269PubMed:20071344}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	37 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001010	sequence-specific DNA binding transcription factor recruiting transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001221	transcription cofactor binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0035014	phosphatidylinositol 3-kinase regulator activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007500	mesodermal cell fate determination
GO:0008285	negative regulation of cell proliferation
GO:0009913	epidermal cell differentiation
GO:0010033	response to organic substance
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
GO:0014740	negative regulation of muscle hyperplasia
GO:0019827	stem cell maintenance
GO:0030154	cell differentiation
GO:0031077	post-embryonic camera-type eye development
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032526	response to retinoic acid
GO:0034115	negative regulation of heterotypic cell-cell adhesion
GO:0035166	post-embryonic hemopoiesis
GO:0042127	regulation of cell proliferation
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043551	regulation of phosphatidylinositol 3-kinase activity
GO:0045415	negative regulation of interleukin-8 biosynthetic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045444	fat cell differentiation
GO:0045595	regulation of cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046985	positive regulation of hemoglobin biosynthetic process
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0048730	epidermis morphogenesis
GO:0050728	negative regulation of inflammatory response
GO:0051247	positive regulation of protein metabolic process
GO:0051898	negative regulation of protein kinase B signaling
GO:0060761	negative regulation of response to cytokine stimulus
GO:0070301	cellular response to hydrogen peroxide
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0071363	cellular response to growth factor stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071409	cellular response to cycloheximide
GO:0071499	cellular response to laminar fluid shear stress
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
GO:1901653	cellular response to peptide
GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production