Version 5.4
Homo sapiens Protein: NXF5
Summary
InnateDB Protein IDBP-79948.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NXF5
Protein Name nuclear RNA export factor 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361889
InnateDB Gene IDBG-79944 (NXF5)
Protein Structure
UniProt Annotation
Function Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons.
Subcellular Localization Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm of cells and more particularly in the cell body and neurites of hippocampal neurons. Although nuclear localization is also observed. Not detected at nuclear rim.
Disease Associations Note=A chromosomal aberration involving NXF5 has been observed in one patient with a syndromic form of mental retardation and short stature. Pericentric inversion inv(X)(p21.1;q22) that interrupts NXF5.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006406 mRNA export from nucleus
GO:0007275 multicellular organismal development
GO:0050658 RNA transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR015245 Nuclear RNA export factor Tap, RNA-binding domain
PFAM PF09162
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H1B4
PhosphoSite PhosphoSite-Q9H1B4
TrEMBL
UniProt Splice Variant
Entrez Gene 55998
UniGene Hs.307077
RefSeq XP_005262222
HUGO HGNC:8075
OMIM 300319
CCDS
HPRD 02263
IMGT
EMBL AJ277654 AJ277655 AJ277656 AJ277657 AJ277658 AL672207 BC131708 Z70228
GenPept AAI31709 CAC20428 CAC20429 CAC20430 CAC20431 CAC20432 CAI42475 CAI42476 CAI42477 CAI42478

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca