InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PREX1

Summary

InnateDB Protein

IDBP-79991.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PREX1

Protein Name

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361009

InnateDB Gene

IDBG-79989 (PREX1)

Protein Structure

UniProt Annotation

Function

Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

Subcellular Localization

Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane.

Disease Associations

Tissue Specificity

Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0019899	enzyme binding

Biological Process

GO:0006801	superoxide metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0030041	actin filament polymerization
GO:0030217	T cell differentiation
GO:0030593	neutrophil chemotaxis
GO:0030833	regulation of actin filament polymerization
GO:0032321	positive regulation of Rho GTPase activity
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0042119	neutrophil activation
GO:0045785	positive regulation of cell adhesion
GO:0050773	regulation of dendrite development
GO:0072593	reactive oxygen species metabolic process
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030426	growth cone
GO:0043198	dendritic shaft
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm