InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PREX1

Summary

InnateDB Gene

IDBG-79989.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PREX1

Gene Name

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000124126

Encoded Proteins

IDBP-79991

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

IDBP-587980

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

IDBP-807312

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:48624252-48827883

Strand

Reverse strand

Band

q13.13

Transcripts

ENST00000371941	ENSP00000361009
ENST00000482556	ENSP00000434632
ENST00000496915
ENST00000620554	ENSP00000481444

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0019899	enzyme binding

Biological Process

GO:0006801	superoxide metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0030041	actin filament polymerization
GO:0030217	T cell differentiation
GO:0030593	neutrophil chemotaxis
GO:0030833	regulation of actin filament polymerization
GO:0032321	positive regulation of Rho GTPase activity
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0042119	neutrophil activation
GO:0045785	positive regulation of cell adhesion
GO:0050773	regulation of dendrite development
GO:0072593	reactive oxygen species metabolic process
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030426	growth cone
GO:0043198	dendritic shaft
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000039621

View Gene Order

ENSBTAG00000015609

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04062

Chemokine signaling pathway pathway

INOH

PID NCI

rac1_reg_pathway

Regulation of RAC1 activity

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.153310 Hs.708321 Hs.741828

RefSeq

NM_020820 XM_005260471

HUGO

OMIM

CCDS

CCDS13410

HPRD

06066

IMGT

EMBL

GenPept

RNA Seq Atlas