InnateDB Protein
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IDBP-80072.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SFTPA2
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Protein Name
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surfactant protein A2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000361402
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InnateDB Gene
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IDBG-80070 (SFTPA2)
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Protein Structure
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Function |
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
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Subcellular Localization |
Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
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Disease Associations |
Pulmonary fibrosis, idiopathic (IPF) [MIM:178500]: A lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease. {ECO:0000269PubMed:19100526}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
6
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001304
C-type lectin
IPR008160
Collagen triple helix repeat
IPR016187
C-type lectin fold
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PFAM |
PF00059
PF01391
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PRINTS |
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PIRSF |
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SMART |
SM00034
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IWL1
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PhosphoSite |
PhosphoSite-Q8IWL1
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TrEMBL |
X6REF7
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UniProt Splice Variant |
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Entrez Gene |
729238
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UniGene |
Hs.523084
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RefSeq |
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HUGO |
HGNC:10799
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OMIM |
178642
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CCDS |
CCDS41540
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HPRD |
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IMGT |
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EMBL |
AK298074
AK316192
AK316196
AY206682
BC111571
BC139727
BC157866
BC157890
BX248123
HQ021421
HQ021422
HQ021423
HQ021424
HQ021427
HQ021428
HQ021429
HQ021430
K03475
M68519
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GenPept |
AAA36520
AAA60319
AAI11572
AAI39728
AAI57867
AAI57891
AAO13490
ADO27664
ADO27665
ADO27666
ADO27667
ADO27670
ADO27671
ADO27672
ADO27673
BAH12720
BAH14563
BAH14567
CAI16061
CAI16062
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