InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STAU1

Summary

InnateDB Protein

IDBP-80170.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAU1

Protein Name

staufen, RNA binding protein, homolog 1 (Drosophila)

Synonyms

PPP1R150; STAU;

Species

Homo sapiens

Ensembl Protein

ENSP00000360893

InnateDB Gene

IDBG-80162 (STAU1)

Protein Structure

UniProt Annotation

Function

Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19029303}. Rough endoplasmic reticulum {ECO:0000269PubMed:19029303}. Note=Localizes exclusively with the rough reticulum endoplasmic (RER).

Disease Associations

Tissue Specificity

Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 307 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	307 [view]
Protein-Protein	304 [view]
Protein-DNA	0
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

Cellular Component

GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum
GO:0005875	microtubule associated complex
GO:0010494	cytoplasmic stress granule
GO:0016020	membrane
GO:0030425	dendrite
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome