InnateDB Protein
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IDBP-80174.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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STAU1
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Protein Name
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staufen, RNA binding protein, homolog 1 (Drosophila)
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Synonyms
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PPP1R150; STAU;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000353604
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InnateDB Gene
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IDBG-80162 (STAU1)
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Protein Structure
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Function |
Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:19029303}. Rough endoplasmic reticulum {ECO:0000269PubMed:19029303}. Note=Localizes exclusively with the rough reticulum endoplasmic (RER).
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 307 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
307
[view]
|
Protein-Protein |
304
[view]
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Protein-DNA |
0
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Protein-RNA |
3
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR014720
Double-stranded RNA-binding domain
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PFAM |
PF00035
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PRINTS |
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PIRSF |
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SMART |
SM00358
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TIGRFAMs |
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Modification |
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SwissProt |
O95793
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PhosphoSite |
PhosphoSite-O95793
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TrEMBL |
B3KRE0
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UniProt Splice Variant |
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Entrez Gene |
6780
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UniGene |
Hs.714254
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RefSeq |
NP_059346
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HUGO |
HGNC:11370
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OMIM |
601716
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CCDS |
CCDS13415
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HPRD |
03422
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IMGT |
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EMBL |
AF061938
AF061939
AF061940
AF061941
AJ132258
AK091405
AK292859
AL133174
AL136601
AY529074
AY546099
BC050432
BC095397
CH471077
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GenPept |
AAD17530
AAD17531
AAD17532
AAD17533
AAH50432
AAH95397
AAS76636
AAS76637
BAF85548
BAG52352
CAB40082
CAB66536
CAC14084
CAC14085
CAI42820
EAW75669
EAW75671
EAW75672
EAW75673
EAW75674
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