InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANXA11

Summary

InnateDB Protein

IDBP-80298.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANXA11

Protein Name

annexin A11

Synonyms

ANX11; CAP50;

Species

Homo sapiens

Ensembl Protein

ENSP00000361305

InnateDB Gene

IDBG-80290 (ANXA11)

Protein Structure

UniProt Annotation

Function

Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. {ECO:0000250, ECO:0000269PubMed:15197175}.

Subcellular Localization

Cytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell- cycle dependent. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding
GO:0023026	MHC class II protein complex binding
GO:0044548	S100 protein binding
GO:0044822	poly(A) RNA binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006909	phagocytosis
GO:0007109	cytokinesis, completion of separation
GO:0051592	response to calcium ion

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0016020	membrane
GO:0030496	midbody
GO:0042470	melanosome
GO:0042581	specific granule
GO:0042582	azurophil granule
GO:0045335	phagocytic vesicle
GO:0070062	extracellular vesicular exosome