Version 5.4
Homo sapiens Protein: BHLHB9
Summary
InnateDB Protein IDBP-80350.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BHLHB9
Protein Name basic helix-loop-helix domain containing, class B, 9
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000354675
InnateDB Gene IDBG-80346 (BHLHB9)
Protein Structure
UniProt Annotation
Function May play a role in the control of cellular aging and survival.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15034937}. Nucleus {ECO:0000269PubMed:15034937}. Note=Mainly cytoplasmic, and nuclear at lower level.
Disease Associations
Tissue Specificity Highly expressed in brain. Not expressed in lung or liver. Down-regulated in brain from patients suffering from Alzheimer disease. {ECO:0000269PubMed:15034937}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007611 learning or memory
GO:0043524 negative regulation of neuron apoptotic process
GO:0050769 positive regulation of neurogenesis
GO:0051965 positive regulation of synapse assembly
GO:0061003 positive regulation of dendritic spine morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR006911 Armadillo repeat-containing domain
IPR016024 Armadillo-type fold
PFAM PF04826
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PI77
PhosphoSite PhosphoSite-Q6PI77
TrEMBL
UniProt Splice Variant
Entrez Gene 80823
UniGene Hs.603894
RefSeq NP_085142
HUGO HGNC:29353
OMIM 300921
CCDS CCDS14502
HPRD 10028
IMGT
EMBL AB051488 AF547055 AL035427 BC041409 CH471190
GenPept AAH41409 AAQ12077 BAB21792 CAI43061 EAW54726

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca