InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGPAT1

Summary

InnateDB Protein

IDBP-80403.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGPAT1

Protein Name

1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)

Synonyms

1-AGPAT1; G15; LPAAT-alpha; LPAATA;

Species

Homo sapiens

Ensembl Protein

ENSP00000364248

InnateDB Gene

IDBG-80399 (AGPAT1)

Protein Structure

UniProt Annotation

Function

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. {ECO:0000269PubMed:21873652}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:21873652}; Multi-pass membrane protein {ECO:0000269PubMed:21873652}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in adipose tissue and at high levels in testis and pancreas. Expressed at lower levels in tissues such as heart, brain, placenta, kidney, lung, spleen, thymus, prostate, ovary, intestine, colon, leukocyte and liver. {ECO:0000269PubMed:21873652}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0001819	positive regulation of cytokine production
GO:0001961	positive regulation of cytokine-mediated signaling pathway
GO:0006112	energy reserve metabolic process
GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0008152	metabolic process
GO:0008654	phospholipid biosynthetic process
GO:0016024	CDP-diacylglycerol biosynthetic process
GO:0019432	triglyceride biosynthetic process
GO:0031325	positive regulation of cellular metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process