InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNB1

Summary

InnateDB Protein

IDBP-80503.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNB1

Protein Name

potassium voltage-gated channel, Shab-related subfamily, member 1

Synonyms

DRK1; h-DRK1; KV2.1;

Species

Homo sapiens

Ensembl Protein

ENSP00000360806

InnateDB Gene

IDBG-80501 (KCNB1)

Protein Structure

UniProt Annotation

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0015271	outward rectifier potassium channel activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0051259	protein oligomerization
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0030425	dendrite
GO:0032590	dendrite membrane
GO:0032809	neuronal cell body membrane
GO:0043025	neuronal cell body
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003968 Potassium channel, voltage dependent, Kv
IPR003969 Potassium channel, voltage dependent, Kv6
IPR003970 Potassium channel, voltage dependent, Kv8.1
IPR003971 Potassium channel, voltage dependent, Kv9
IPR003973 Potassium channel, voltage dependent, Kv2
IPR003974 Potassium channel, voltage dependent, Kv3
IPR004350 Potassium channel, voltage dependent, Kv2.1
IPR005821 Ion transport domain
IPR011333 BTB/POZ fold
IPR013099 Two pore domain potassium channel domain

PFAM

PF02214
PF03521
PF00520
PF07885

PRINTS