Version 5.4
Homo sapiens Protein: NGFRAP1
Summary
InnateDB Protein IDBP-80579.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NGFRAP1
Protein Name nerve growth factor receptor (TNFRSF16) associated protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361728
InnateDB Gene IDBG-80577 (NGFRAP1)
Protein Structure
UniProt Annotation
Function May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases. {ECO:0000250}.
Subcellular Localization Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver. {ECO:0000269PubMed:15958283}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005123 death receptor binding
GO:0005515 protein binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0046872 metal ion binding
Biological Process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007275 multicellular organismal development
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR007623 Brain-expressed X-linked protein
IPR021156 Transcription elongation factor A-like/Brain expressed X-linked-like
PFAM PF04538
PRINTS
PIRSF PIRSF008633
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q00994
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 27018
UniGene Hs.448588
RefSeq NP_996798
HUGO HGNC:13388
OMIM 300361
CCDS CCDS14508
HPRD 02291
IMGT
EMBL AF187064 AK315371 AL606763 AY833562 BC003190 CH471190 EL953547 M38188
GenPept AAA63232 AAF75129 AAH03190 AAX40680 BAG37764 EAW54710 EAW54712

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca