Version 5.4
Homo sapiens Gene: NGFRAP1
Summary
InnateDB Gene IDBG-80577.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NGFRAP1
Gene Name nerve growth factor receptor (TNFRSF16) associated protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166681
Encoded Proteins
IDBP-80579
nerve growth factor receptor (TNFRSF16) associated protein 1
IDBP-80583
nerve growth factor receptor (TNFRSF16) associated protein 1
IDBP-80585
nerve growth factor receptor (TNFRSF16) associated protein 1
IDBP-80587
nerve growth factor receptor (TNFRSF16) associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome X:103376340-103378077
Strand Forward strand
Band q22.2
Transcripts
ENST00000372645 ENSP00000361728
ENST00000361298 ENSP00000354843
ENST00000372635 ENSP00000361718
ENST00000372634 ENSP00000361717
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005123 death receptor binding
GO:0005515 protein binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0046872 metal ion binding
Biological Process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007275 multicellular organismal development
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000046432
View Gene Order
ENSBTAG00000006026
Not yet available
Pathways
NETPATH
REACTOME
REACT_13526
NADE modulates death signalling pathway
REACT_11061
Signalling by NGF pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
hsa04722
Neurotrophin signaling pathway pathway
INOH
PID NCI
p75ntrpathway
p75(NTR)-mediated signaling
Cross-References
SwissProt Q00994
TrEMBL
UniProt Splice Variant
Entrez Gene 27018
UniGene Hs.448588
RefSeq NM_001282674 NM_014380 NM_206915 NM_206917
HUGO HGNC:13388
OMIM 300361
CCDS CCDS14508 CCDS14509
HPRD
IMGT
EMBL AF187064 AK315371 AL606763 AY833562 BC003190 CH471190 EL953547 M38188
GenPept AAA63232 AAF75129 AAH03190 AAX40680 BAG37764 EAW54710 EAW54712
RNA Seq Atlas 27018

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca