InnateDB Protein
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IDBP-80592.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC9A8
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Protein Name
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solute carrier family 9 (sodium/hydrogen exchanger), member 8
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Synonyms
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NHE-8; NHE8;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000354966
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InnateDB Gene
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IDBG-80588 (SLC9A8)
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Protein Structure
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Function |
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. {ECO:0000269PubMed:15522866}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000269PubMed:15522866}; Multi-pass membrane protein {ECO:0000269PubMed:15522866}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Strongly expressed in skeletal muscle and kidney. {ECO:0000269PubMed:15522866}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0015299
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solute:proton antiporter activity
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GO:0015385
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sodium:proton antiporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004709
Na+/H+ exchanger
IPR006153
Cation/H+ exchanger
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PFAM |
PF00999
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PRINTS |
PR01084
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y2E8
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PhosphoSite |
PhosphoSite-Q9Y2E8
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TrEMBL |
B7Z3B1
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UniProt Splice Variant |
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Entrez Gene |
23315
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UniGene |
Hs.444202
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RefSeq |
NP_056081
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HUGO |
HGNC:20728
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OMIM |
612730
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CCDS |
CCDS13421
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HPRD |
18062
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IMGT |
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EMBL |
AB023156
AK131001
AK295665
AK295803
AK300318
AL031685
AL162615
BC112213
CH471077
CR749638
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GenPept |
AAI12214
BAA76783
BAC85475
BAG58621
BAG62070
BAH12147
CAH18432
CAI18970
CAI23460
EAW75649
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