Version 5.4
Homo sapiens Gene: SLC9A8
Summary
InnateDB Gene IDBG-80588.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC9A8
Gene Name solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
Synonyms NHE-8; NHE8
Species Homo sapiens
Ensembl Gene ENSG00000197818
Encoded Proteins
IDBP-80592
solute carrier family 9 (sodium/hydrogen exchanger), member 8
IDBP-378316
solute carrier family 9 (sodium/hydrogen exchanger), member 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:49812713-49892242
Strand Forward strand
Band q13.13
Transcripts
ENST00000361573 ENSP00000354966
ENST00000417961 ENSP00000416418
ENST00000489787
ENST00000490250
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015299 solute:proton antiporter activity
GO:0015385 sodium:proton antiporter activity
GO:0015386 potassium:hydrogen antiporter activity
Biological Process
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006885 regulation of pH
GO:0035725 sodium ion transmembrane transport
GO:0051453 regulation of intracellular pH
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039463
View Gene Order
ENSBTAG00000008969
Not yet available
Pathways
NETPATH
REACTOME
REACT_19314
Sodium/Proton exchangers pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9Y2E8
TrEMBL B4DIV9 B7Z3B1
UniProt Splice Variant
Entrez Gene 23315
UniGene Hs.444202
RefSeq NM_015266 XM_006723757 XM_006723758 NM_001260491
HUGO HGNC:20728
OMIM 612730
CCDS CCDS13421 CCDS58774
HPRD 18062
IMGT
EMBL AB023156 AK131001 AK295665 AK295803 AK300318 AL031685 AL162615 BC112213 CH471077 CR749638
GenPept AAI12214 BAA76783 BAC85475 BAG58621 BAG62070 BAH12147 CAH18432 CAI18970 CAI23460 EAW75649
RNA Seq Atlas 23315

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca