InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOTCH4

Summary

InnateDB Protein

IDBP-80603.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOTCH4

Protein Name

notch 4

Synonyms

INT3;

Species

Homo sapiens

Ensembl Protein

ENSP00000364163

InnateDB Gene

IDBG-80593 (NOTCH4)

Protein Structure

UniProt Annotation

Function

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.Notch 4 intracellular domain: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.

Disease Associations

Tissue Specificity

Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001569	patterning of blood vessels
GO:0001709	cell fate determination
GO:0001763	morphogenesis of a branching structure
GO:0001886	endothelial cell morphogenesis
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007221	positive regulation of transcription of Notch receptor target
GO:0007275	multicellular organismal development
GO:0009790	embryo development
GO:0010467	gene expression
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0030879	mammary gland development
GO:0045446	endothelial cell differentiation
GO:0045596	negative regulation of cell differentiation
GO:0045602	negative regulation of endothelial cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050793	regulation of developmental process

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000800 Notch domain
IPR001881 EGF-like calcium-binding domain
IPR002110 Ankyrin repeat
IPR008297 Notch
IPR011656 Notch, NODP domain
IPR020683 Ankyrin repeat-containing domain
IPR022355 Neurogenic locus Notch 4

PFAM