InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NOTCH4

Summary

InnateDB Gene

IDBG-80593.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOTCH4

Gene Name

notch 4

Synonyms

INT3

Species

Homo sapiens

Ensembl Gene

ENSG00000204301

Encoded Proteins

IDBP-80603

notch 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:32194843-32224067

Strand

Reverse strand

Band

p21.32

Transcripts

ENST00000375023	ENSP00000364163
ENST00000474612
ENST00000491215
ENST00000465528
ENST00000473562

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001569	patterning of blood vessels
GO:0001709	cell fate determination
GO:0001763	morphogenesis of a branching structure
GO:0001886	endothelial cell morphogenesis
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007221	positive regulation of transcription of Notch receptor target
GO:0007275	multicellular organismal development
GO:0009790	embryo development
GO:0010467	gene expression
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0030879	mammary gland development
GO:0045446	endothelial cell differentiation
GO:0045596	negative regulation of cell differentiation
GO:0045602	negative regulation of endothelial cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050793	regulation of developmental process

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane