InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRLR

Summary

InnateDB Protein

IDBP-806274.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRLR

Protein Name

prolactin receptor

Synonyms

HPRL; hPRLrI; MFAB;

Species

Homo sapiens

Ensembl Protein

ENSP00000482954

InnateDB Gene

IDBG-15793 (PRLR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	30 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004925	prolactin receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0042803	protein homodimerization activity
GO:0042978	ornithine decarboxylase activator activity
GO:0046872	metal ion binding

Biological Process

GO:0006694	steroid biosynthetic process
GO:0007166	cell surface receptor signaling pathway
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007259	JAK-STAT cascade
GO:0007566	embryo implantation
GO:0007595	lactation
GO:0030155	regulation of cell adhesion
GO:0030856	regulation of epithelial cell differentiation
GO:0038161	prolactin signaling pathway
GO:0042110	T cell activation
GO:0042977	activation of JAK2 kinase activity
GO:0043066	negative regulation of apoptotic process
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060644	mammary gland epithelial cell differentiation
GO:0060736	prostate gland growth
GO:0060749	mammary gland alveolus development
GO:0061180	mammary gland epithelium development