InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GMNN

Summary

InnateDB Protein

IDBP-806458.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GMNN

Protein Name

geminin, DNA replication inhibitor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000477506

InnateDB Gene

IDBG-65780 (GMNN)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042826	histone deacetylase binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006275	regulation of DNA replication
GO:0008156	negative regulation of DNA replication
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR022786 Geminin/Multicilin

PFAM

PF07412

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF067855 AK021685 AL133264 BC005185 BC005389 CH471087

GenPept

AAC39787 AAH05185 AAH05389 BAG51040 CAC21511 EAW55465 EAW55466

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca