InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGF2

Summary

InnateDB Protein

IDBP-806475.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF2

Protein Name

fibroblast growth factor 2 (basic)

Synonyms

BFGF; FGF-2; FGFB; HBGF-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000477134

InnateDB Gene

IDBG-37039 (FGF2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	31 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0042056	chemoattractant activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0006661	phosphatidylinositol biosynthetic process
GO:0006935	chemotaxis
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007265	Ras protein signal transduction
GO:0007399	nervous system development
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009887	organ morphogenesis
GO:0010764	negative regulation of fibroblast migration
GO:0010863	positive regulation of phospholipase C activity
GO:0030198	extracellular matrix organization
GO:0030214	hyaluronan catabolic process
GO:0032958	inositol phosphate biosynthetic process
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042060	wound healing
GO:0042660	positive regulation of cell fate specification
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087	innate immune response
GO:0045765	regulation of angiogenesis
GO:0045766	positive regulation of angiogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048598	embryonic morphogenesis
GO:0050918	positive chemotaxis
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051781	positive regulation of cell division
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060548	negative regulation of cell death
GO:0060591	chondroblast differentiation
GO:0061045	negative regulation of wound healing
GO:0070374	positive regulation of ERK1 and ERK2 cascade