InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNAI1

Summary

InnateDB Protein

IDBP-80678.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNAI1

Protein Name

snail homolog 1 (Drosophila)

Synonyms

dJ710H13.1; SLUGH2; SNA; SNAH; SNAIL; SNAIL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000244050

InnateDB Gene

IDBG-80676 (SNAI1)

Protein Structure

UniProt Annotation

Function

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. {ECO:0000269PubMed:10655587, ECO:0000269PubMed:15647282, ECO:0000269PubMed:16096638, ECO:0000269PubMed:20121949, ECO:0000269PubMed:20562920, ECO:0000269PubMed:21952048}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.

Disease Associations

Tissue Specificity

Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines. {ECO:0000269PubMed:10655587}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	58 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001649	osteoblast differentiation
GO:0001707	mesoderm formation
GO:0001837	epithelial to mesenchymal transition
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007498	mesoderm development
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010957	negative regulation of vitamin D biosynthetic process
GO:0016477	cell migration
GO:0030335	positive regulation of cell migration
GO:0031069	hair follicle morphogenesis
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060021	palate development
GO:0060536	cartilage morphogenesis
GO:0060707	trophoblast giant cell differentiation
GO:0060806	negative regulation of cell differentiation involved in embryonic placenta development
GO:0060972	left/right pattern formation
GO:0061314	Notch signaling involved in heart development
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000810	regulation of tight junction assembly