InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPARC

Summary

InnateDB Protein

IDBP-806883.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPARC

Protein Name

secreted protein, acidic, cysteine-rich (osteonectin)

Synonyms

ON;

Species

Homo sapiens

Ensembl Protein

ENSP00000480550

InnateDB Gene

IDBG-54562 (SPARC)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005518	collagen binding

Biological Process

GO:0002576	platelet degranulation
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0031093	platelet alpha granule lumen
GO:0071682	endocytic vesicle lumen

Protein Structure and Domains

PDB ID

InterPro

IPR002350 Kazal domain
IPR003645 Follistatin-like, N-terminal
IPR015369 Follistatin/Osteonectin EGF domain
IPR019577 SPARC/Testican, calcium-binding domain

PFAM

PF00050
PF07648
PF09289
PF10591

PRINTS

PIRSF

SMART

SM00280
SM00274

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite