InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNP1

Summary

InnateDB Protein

IDBP-80763.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNP1

Protein Name

transition protein 1 (during histone to protamine replacement)

Synonyms

TP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000236979

InnateDB Gene

IDBG-80761 (TNP1)

Protein Structure

UniProt Annotation

Function

In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Tissue Specificity

Expressed by spermatids (at protein level). {ECO:0000269PubMed:9809674}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding

Biological Process

GO:0000012	single strand break repair
GO:0006337	nucleosome disassembly
GO:0006338	chromatin remodeling
GO:0006342	chromatin silencing
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0007289	spermatid nucleus differentiation
GO:0007290	spermatid nucleus elongation
GO:0019953	sexual reproduction
GO:0030317	sperm motility
GO:0035042	fertilization, exchange of chromosomal proteins
GO:0045892	negative regulation of transcription, DNA-templated