InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFIT2

Summary

InnateDB Protein

IDBP-807712.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFIT2

Protein Name

interferon-induced protein with tetratricopeptide repeats 2

Synonyms

cig42; G10P2; GARG-39; IFI-54; IFI-54K; IFI54; IFIT-2; ISG-54 K; ISG-54K; ISG54; P54;

Species

Homo sapiens

Ensembl Protein

ENSP00000484770

InnateDB Gene

IDBG-81895 (IFIT2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.

Experimentally validated
Total	54 [view]
Protein-Protein	43 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0008637	apoptotic mitochondrial changes
GO:0009615	response to virus
GO:0019221	cytokine-mediated signaling pathway
GO:0032091	negative regulation of protein binding
GO:0043065	positive regulation of apoptotic process
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat

PFAM

PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

3433

UniGene

RefSeq

HUGO

HGNC:5409

OMIM

147040

CCDS

HPRD

IMGT

EMBL

AL353751 M14659 M14660 X07557

GenPept

AAA59191 CAA30438 CAI12238