Version 5.4
Homo sapiens Gene: IFIT2
Summary
InnateDB Gene IDBG-81895.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFIT2
Gene Name interferon-induced protein with tetratricopeptide repeats 2
Synonyms cig42; G10P2; GARG-39; IFI-54; IFI-54K; IFI54; IFIT-2; ISG-54 K; ISG-54K; ISG54; P54
Species Homo sapiens
Ensembl Gene ENSG00000119922
Encoded Proteins
IDBP-81897
interferon-induced protein with tetratricopeptide repeats 2
IDBP-807712
interferon-induced protein with tetratricopeptide repeats 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19108715
IFIT2 belongs to type 1 interferon response genes and is highly induced after stimulation with LPS and selectively affects LPS induced protein expression by regulation at different post-transcriptional levels.
PMID 22065572
IFIT2 expression imparts anti-viral immunity to restrict West Nile virus infection and control viral pathogenesis. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22065572
[Mus musculus] Ifit2 expression imparts anti-viral immunity to restrict West Nile virus infection and control viral pathogenesis.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:89301955-89309276
Strand Forward strand
Band q23.31
Transcripts
ENST00000371826 ENSP00000360891
ENST00000611722 ENSP00000484770
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
Experimentally validated
Total 54 [view]
Protein-Protein 43 [view]
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008637 apoptotic mitochondrial changes
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0032091 negative regulation of protein binding
GO:0035457 cellular response to interferon-alpha
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000045932
View Gene Order
ENSBTAG00000034918
Not yet available
Pathways
NETPATH
REACTOME
REACT_25162
Interferon alpha/beta signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P09913
TrEMBL
UniProt Splice Variant
Entrez Gene 3433
UniGene Hs.437609
RefSeq NM_001547
HUGO HGNC:5409
OMIM 147040
CCDS CCDS41548
HPRD
IMGT
EMBL AL353751 M14659 M14660 X07557
GenPept AAA59191 CAA30438 CAI12238
RNA Seq Atlas 3433

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca