Version 5.4
Homo sapiens Protein: SLC1A2
Summary
InnateDB Protein IDBP-808016.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC1A2
Protein Name solute carrier family 1 (glial high affinity glutamate transporter), member 2
Synonyms EAAT2; GLT-1;
Species Homo sapiens
Ensembl Protein ENSP00000476124
InnateDB Gene IDBG-39801 (SLC1A2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 6 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005313 L-glutamate transmembrane transporter activity
GO:0005515 protein binding
GO:0017153 sodium:dicarboxylate symporter activity
Biological Process
GO:0006811 ion transport
GO:0006835 dicarboxylic acid transport
GO:0007268 synaptic transmission
GO:0051938 L-glutamate import
GO:0055085 transmembrane transport
GO:0070779 D-aspartate import
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001991 Sodium:dicarboxylate symporter
PFAM PF00375
PRINTS PR00173
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P43004
PhosphoSite PhosphoSite-P43004
TrEMBL
UniProt Splice Variant
Entrez Gene 6506
UniGene
RefSeq
HUGO HGNC:10940
OMIM 600300
CCDS
HPRD
IMGT
EMBL AC090625 AK298769 AL133330 AY066021 BC132768 CH471064 D85884 U01824 U03505 Z32517
GenPept AAA18900 AAA50429 AAI32769 AAL57716 BAA28706 BAG60911 CAA83532 CAM28291 EAW68143

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca