InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GLRA4

Summary

InnateDB Protein

IDBP-80818.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLRA4

Protein Name

glycine receptor, alpha 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361700

InnateDB Gene

IDBG-80816 (GLRA4)

Protein Structure

UniProt Annotation

Function

The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity
GO:0016594	glycine binding
GO:0022824	transmitter-gated ion channel activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0034707	chloride channel complex
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
IPR008127 Glycine receptor alpha

PFAM

PF02932
PF02931

PRINTS

PR00253
PR00252
PR01673

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5JXX5