InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MCM3

Summary

InnateDB Protein

IDBP-808259.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCM3

Protein Name

minichromosome maintenance complex component 3

Synonyms

HCC5; P1-MCM3; P1.h; RLFB;

Species

Homo sapiens

Ensembl Protein

ENSP00000480987

InnateDB Gene

IDBG-90549 (MCM3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 130 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	130 [view]
Protein-Protein	122 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016851	magnesium chelatase activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006270	DNA replication initiation
GO:0006271	DNA strand elongation involved in DNA replication
GO:0015979	photosynthesis
GO:0015995	chlorophyll biosynthetic process
GO:0032508	DNA duplex unwinding

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005658	alpha DNA polymerase:primase complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0016020	membrane
GO:0042555	MCM complex
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000523 Magnesium chelatase, ChlI subunit
IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase
IPR003593 AAA+ ATPase domain
IPR008046 DNA replication licensing factor Mcm3
IPR012340 Nucleic acid-binding, OB-fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01078
PF00493

PRINTS

PR01657
PR01659

PIRSF

SMART

SM00350
SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt