InnateDB Protein
|
IDBP-80844.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
ARPC2
|
Protein Name
|
actin related protein 2/3 complex, subunit 2, 34kDa
|
Synonyms
|
ARC34; p34-Arc; PNAS-139;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000295685
|
InnateDB Gene
|
IDBG-80840 (ARPC2)
|
Protein Structure
|
|
Function |
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
|
Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:9230079}. Cell projection {ECO:0000269PubMed:9230079}. Cell junction, synapse, synaptosome {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
65
[view]
|
Protein-Protein |
65
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
4 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0006928
|
cellular component movement
|
GO:0010592
|
positive regulation of lamellipodium assembly
|
GO:0030833
|
regulation of actin filament polymerization
|
GO:0030838
|
positive regulation of actin filament polymerization
|
GO:0034314
|
Arp2/3 complex-mediated actin nucleation
|
GO:0038096
|
Fc-gamma receptor signaling pathway involved in phagocytosis
|
GO:0045087
|
innate immune response
|
GO:1900026
|
positive regulation of substrate adhesion-dependent cell spreading
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR007188
ARP2/3 complex, 34kDa subunit (p34-Arc)
|
PFAM |
PF04045
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O15144
|
PhosphoSite |
PhosphoSite-O15144
|
TrEMBL |
Q53R19
|
UniProt Splice Variant |
|
Entrez Gene |
10109
|
UniGene |
Hs.708554
|
RefSeq |
NP_005722
|
HUGO |
HGNC:705
|
OMIM |
604224
|
CCDS |
CCDS2410
|
HPRD |
10367
|
IMGT |
|
EMBL |
AC021016
AC097483
AF006085
AF116702
AK290268
BC000590
BT006898
CH471063
U50523
|
GenPept |
AAB64190
AAC50874
AAF71122
AAH00590
AAP35544
AAX93213
BAF82957
EAW70591
EAW70592
EAW70593
EAW70597
|
|
|