Version 5.4
Homo sapiens Gene: ARPC2
Summary
InnateDB Gene IDBG-80840.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARPC2
Gene Name actin related protein 2/3 complex, subunit 2, 34kDa
Synonyms ARC34; p34-Arc; PNAS-139
Species Homo sapiens
Ensembl Gene ENSG00000163466
Encoded Proteins
IDBP-80842
actin related protein 2/3 complex, subunit 2, 34kDa
IDBP-80844
actin related protein 2/3 complex, subunit 2, 34kDa
IDBP-388862
actin related protein 2/3 complex, subunit 2, 34kDa
IDBP-388866
actin related protein 2/3 complex, subunit 2, 34kDa
IDBP-388867
actin related protein 2/3 complex, subunit 2, 34kDa
IDBP-388868
actin related protein 2/3 complex, subunit 2, 34kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:218217094-218254356
Strand Forward strand
Band q35
Transcripts
ENST00000315717 ENSP00000327137
ENST00000295685 ENSP00000295685
ENST00000420104 ENSP00000401070
ENST00000420201 ENSP00000396475
ENST00000414983 ENSP00000412632
ENST00000456575 ENSP00000411612
ENST00000489598
ENST00000491780
ENST00000478612
ENST00000480062
ENST00000465395
ENST00000472753
ENST00000471355
ENST00000484961
ENST00000470146
ENST00000477992
ENST00000462034
ENST00000487321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 65 [view]
Protein-Protein 65 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0019894 kinesin binding
GO:0035650 AP-1 adaptor complex binding
GO:0071933 Arp2/3 complex binding
Biological Process
GO:0006928 cellular component movement
GO:0010592 positive regulation of lamellipodium assembly
GO:0030833 regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0031252 cell leading edge
GO:0043005 neuron projection
GO:0045202 synapse
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006304
View Gene Order
ENSBTAG00000010386
Not yet available
Pathways
NETPATH
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_111045
Developmental Biology pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_6802
Innate Immune System pathway
REACT_18266
Axon guidance pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
INOH
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
rac1_pathway
RAC1 signaling pathway
cdc42_pathway
CDC42 signaling events
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.708554
RefSeq NM_005731 NM_152862 XM_006712173
HUGO
OMIM
CCDS CCDS2410
HPRD 10367
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca