InnateDB Protein
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IDBP-80862.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CEBPB
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Protein Name
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CCAAT/enhancer binding protein (C/EBP), beta
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Synonyms
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C/EBP-beta; IL6DBP; NF-IL6; TCF5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000305422
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InnateDB Gene
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IDBG-80858 (CEBPB)
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Protein Structure
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Function |
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Plays an important role in adipose tissue differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG) as well as other adipogenesis key player genes. {ECO:0000269PubMed:20829347}.Isoform 3: acts as a dominant negative through heterodimerization with isoform 2. {ECO:0000269PubMed:20829347}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00978, ECO:0000269PubMed:20829347}.
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Disease Associations |
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Tissue Specificity |
Expressed at low levels in the lung, kidney and spleen.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 169 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated |
Total |
169
[view]
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Protein-Protein |
104
[view]
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Protein-DNA |
63
[view]
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
41 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003677
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DNA binding
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GO:0003682
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chromatin binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0003705
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RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0008134
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transcription factor binding
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GO:0035259
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glucocorticoid receptor binding
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GO:0042803
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protein homodimerization activity
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GO:0043565
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sequence-specific DNA binding
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GO:0046982
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protein heterodimerization activity
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Biological Process |
GO:0001892
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embryonic placenta development
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0006953
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acute-phase response
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GO:0006954
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inflammatory response
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GO:0006955
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immune response
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GO:0030182
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neuron differentiation
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GO:0032496
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response to lipopolysaccharide
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GO:0033598
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mammary gland epithelial cell proliferation
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GO:0034976
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response to endoplasmic reticulum stress
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GO:0043524
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negative regulation of neuron apoptotic process
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GO:0045087
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innate immune response (InnateDB)
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GO:0045408
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regulation of interleukin-6 biosynthetic process
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GO:0045444
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fat cell differentiation
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GO:0045600
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positive regulation of fat cell differentiation
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GO:0045669
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positive regulation of osteoblast differentiation
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0050873
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brown fat cell differentiation
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GO:0060644
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mammary gland epithelial cell differentiation
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GO:0060850
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regulation of transcription involved in cell fate commitment
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GO:0071230
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cellular response to amino acid stimulus
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Cellular Component |
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PDB ID |
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InterPro |
IPR004827
Basic-leucine zipper domain
IPR016468
CCAAT/enhancer-binding
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PFAM |
PF00170
PF07716
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PRINTS |
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PIRSF |
PIRSF005879
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SMART |
SM00338
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TIGRFAMs |
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Modification |
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SwissProt |
P17676
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PhosphoSite |
PhosphoSite-P17676
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TrEMBL |
W8SNV5
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UniProt Splice Variant |
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Entrez Gene |
1051
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UniGene |
Hs.719041
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RefSeq |
NP_005185
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HUGO |
HGNC:1834
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OMIM |
189965
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CCDS |
CCDS13429
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HPRD |
01801
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IMGT |
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EMBL |
AF289608
AK291536
AL161937
AY193834
BC005132
BC007538
BC021931
CH471077
KJ161450
KJ161451
KJ161452
KJ161453
KJ161454
KJ161455
KJ161456
KJ161457
KJ161458
KJ161459
KJ161460
KJ161461
KJ161462
KJ161463
KJ161464
KJ161465
KJ161466
KJ161470
KJ161471
KJ161472
KJ161473
KJ161474
KJ161475
KJ161476
KJ161477
KJ161478
KJ161479
KJ161480
KJ161481
X52560
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GenPept |
AAH05132
AAH07538
AAH21931
AAL55792
AAN86350
AHM26727
AHM26728
AHM26729
AHM26730
AHM26731
AHM26732
AHM26733
AHM26734
AHM26735
AHM26736
AHM26737
AHM26738
AHM26739
AHM26740
AHM26741
AHM26742
AHM26743
AHM26747
AHM26748
AHM26749
AHM26750
AHM26751
AHM26752
AHM26753
AHM26754
AHM26755
AHM26756
AHM26757
AHM26758
BAF84225
CAA36794
CAC14276
EAW75629
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