InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALOX5AP

Summary

InnateDB Protein

IDBP-808875.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALOX5AP

Protein Name

arachidonate 5-lipoxygenase-activating protein

Synonyms

FLAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000479870

InnateDB Gene

IDBG-21438 (ALOX5AP)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	4 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004051	arachidonate 5-lipoxygenase activity
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding
GO:0050544	arachidonic acid binding

Biological Process

GO:0002540	leukotriene production involved in inflammatory response
GO:0002675	positive regulation of acute inflammatory response
GO:0006691	leukotriene metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019370	leukotriene biosynthetic process
GO:0019372	lipoxygenase pathway
GO:0043085	positive regulation of catalytic activity
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070207	protein homotrimerization
GO:0071277	cellular response to calcium ion
GO:2001300	lipoxin metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane